Mattias Belting : Translational studies on the role of exosomes and lipoproteins in glioblastoma

Dates de l'évènement : 27/03/2018 13:00
Organisateur : Pascale Zimmermann
Lieu : IPC2
Catégorie : Séminaires externes

Université de Lund, Suède

Mattias Belting is professor and senior consultant of Neuro-Oncology at Lund University, Sweden. Following a PhD in medicinal chemistry and postdocs at UCSD and Scripps, La Jolla, his current research focus is on lipid vesicles (exosomes, endosomes, lipoproteins) as mediators, treatment targets, and biomarkers in cancer.


1. Menard JA, Christianson HC, Kucharzewska P, Bourseau-Guilmain E, Svensson KJ, Lindqvist E, Chandran VI, Kjellén L, Welinder C, Bengzon J, Johansson MC, Belting M. Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan Dependent Endocytosis. Cancer Research (2016) 76:4828-4840.

2. Bourseau-Guilmain E, Menard JA, Lindqvist E, Indira Chandran V, Christianson HC, Cerezo Magaña M, Lidfeldt J, Marko-Varga G, Welinder C, Belting M. Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells. Nature Communications (2016) 20:11371-83.

3. Kucharzewska P, Christianson HC, Welch JE, Svensson KJ, Fredlund E, Ringnér M, Mörgelin M, Bourseau-Guilmain E, Bengzon J, Belting M. Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. Proceedings of the National Academy of Sciences USA (2013) 110:7312-7.