The Centre de Recherche en Cancérologie de Marseille (CRCM, Cancer Research Center of Marseille) affiliated to Inserm (UMR1068), CNRS (UMR7258) and Aix-Marseille University (UM105) is an original center in the landscape of French research. This originality is not only due to its location in the heart of the Institut Paoli-Calmettes (IPC) but also to his vocation: to advance the biology and medicine of cancer while working at the physiological and pathological interface, the fundamental and the applied, research and the clinic. This continuum between basic research, translational research and clinical research is really the hallmark of the CRCM. As an example, most of our publications are co-authored by scientists and clinicians, which is far from the norm in our discipline.
We explore communication networks (signals, surface receptors, communication nodes...) that regulate the action of cancer cells and immune cells and seek to identify genetic alterations (from point mutations of a gene to complex chromosomal abnormalities) leading to the transformation of a healthy cell into a tumor cell.
This work has already helped improve our understanding of the disease, to better understand how immune cells fight it and the strategies used by tumor cells in an attempt to escape them. They also led to the discovery of new molecular targets that are now the subject of diagnostic and therapeutic applications in oncology.